Alterity study shows QSM MRI tracks iron buildup, severity in multiple system atrophy

• Alterity Therapeutics highlighted a newly published, peer-reviewed NeuroImage study supporting quantitative susceptibility mapping MRI as an imaging biomarker for Multiple System Atrophy, with results already presented in the publication.
• The analysis from the bioMUSE natural history study indicates the imaging method can detect disease-specific brain iron accumulation, help distinguish MSA from Parkinson’s disease, and track clinical severity, including in early-stage disease.
• Alterity said it previously used the approach in its Phase 2 trial of lead candidate ATH434, citing improved diagnostic accuracy and objective evidence of target engagement.
• Company positioned the findings as supportive of earlier diagnosis strategies and as a tool to evaluate iron-modulating therapies in MSA, including ATH434.

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