Polyrizon Announces New Preclinical Data Showing Proprietary Naloxone Hydrogel Adheres To Nasal Tissue Longer Than Approved And Marketed Intranasal Naloxone Spray Product

Superior Mucoadhesion may potentially Translate into More Reliable Opioid Overdose Reversal in Real-World Emergencies

Ra'anana, Israel, Dec. 03, 2025 (GLOBE NEWSWIRE) -- Polyrizon Ltd. (NASDAQ:PLRZ) ("Polyrizon" or the "Company"), a biotechnology company focusing on the development of intranasal products, today announced compelling new preclinical data showing its proprietary naloxone hydrogel adheres to nasal tissue longer than an approved and marketed intranasal naloxone spray product.

Using an established ex-vivo rabbit nasal mucosa model, researchers evaluated the persistence of Polyrizon's hydrogel formulation versus commercial product by applying each formulation to mucosal tissue and washing with Simulated Nasal Electrolyte Solution (SNES) over a 30-minute period. Quantification of residual fluorescence revealed that Polyrizon's hydrogel maintained higher values of the fluorescence marker when compared to the commercial product, with differences reaching high statistical significance (p < 0.0001, two-way ANOVA), indicating notably stronger and more durable mucosal retention.

The results showed that Polyrizon's Trap and Target ™ (T&T) hydrogel exhibited significantly higher mucoadhesion levels compared to the commercial product, supporting potentially prolonged contact at the nasal deposition site and potentially enhancing bioavailability.

Improved mucoadhesion is a critical factor for intranasal drug delivery - particularly for emergency treatments such as opioid overdose reversal - because enhanced residence time at the nasal deposition site can support more reliable absorption and potentially faster onset of action.

This new dataset builds directly on the previously reported encouraging stability results, which demonstrated the robustness of Polyrizon's formulation under various storage conditions. Collectively, stability plus mucoadhesion performance reinforce the potential of Polyrizon's T&T technology to deliver a safer, more reliable, and more effective intranasal Naloxone product.