Why Tempest Therapeutics (TPST) Stock Is Down 45% Today

Tempest Therapeutics Inc (NASDAQ:TPST) shares are trading sharply lower Wednesday morning following the announcement of an all-stock acquisition of dual-CAR T programs from Factor Bioscience. Here’s what investors need to know.

• TPST is among today’s weakest performers. See the trading setup here.

What To Know: While the deal expands Tempest’s pipeline, the market is reacting negatively to significant shareholder dilution. Tempest will issue roughly 8.27 million new shares to Factor, equivalent to 65% of the company's outstanding stock. To mitigate this, existing shareholders will receive warrants exercisable at $18.48 per share.

The transaction creates a leadership shakeup, with Factor co-founder Dr. Matt Angel set to replace Stephen Brady as CEO upon the deal’s expected closing in early 2026.

Strategically, Tempest gains the clinical-stage TPST-2003 program and projects that the deal, alongside new investment commitments, will extend its cash runway into mid-2027.

Benzinga Edge Rankings: Benzinga Edge data currently assigns the stock bearish signals flashing across its short, medium and long-term price trends.

TPST Price Action: Tempest Therapeutics shares were down 50% at $4.60 at the time of publication on Wednesday. The stock is trading near its 52-week low of $4.95, according to Benzinga Pro data.

Read Also: EXCLUSIVE: Alzamend Wraps Clinical Phase Of AL001 Study In Healthy Participants

How To Buy TPST Stock

Besides going to a brokerage platform to purchase a share – or fractional share – of stock, you can also gain access to shares either by buying an exchange traded fund (ETF) that holds the stock itself, or by allocating yourself to a strategy in your 401(k) that would seek to acquire shares in a mutual fund or other instrument.

For example, in Tempest Therapeutics’ case, it is in the Health Care sector. An ETF will likely hold shares in many liquid and large companies that help track that sector, allowing an investor to gain exposure to the trends within that segment.

Image: Shutterstock